منابع مشابه
Opioid tolerance or opioid withdrawal?
To the Editor: We thank Kim et al. for their recent work examining the effect of intraoperative remifentanil on postoperative analgesia in children.1 Certainly, the pharmacokinetic profile of this potent opioid is attractive in modern anesthetic practice, and a thorough understanding of the principles behind tolerance, hyperalgesia, and withdrawal of remifentanil are critical for its safe admin...
متن کاملA RAVE about Opioid Withdrawal
Control of trafficking of g protein-linked receptors is thought to be an important regulatory mechanism for receptor signaling. Finn and Whistler test the hypothesis that agonist-induced trafficking of opioid receptors regulates the development of tolerance and dependence. The results show that measures of tolerance and withdrawal to morphine are decreased under conditions where receptors are t...
متن کاملCreating More Effective Research
TWO KEY QUESTIONS are exercising the minds of pharmaceutical R&D directors at the moment: how to make better use of the available resources, and where to invest for growth. My experience of working with several major pharmaceutical companies over the past ten years shows that sound answers to those questions can be obtained by identifying the areas of greater and lesser opportunity in the portf...
متن کامل154 - Ethanol and Opioid Intoxication and Withdrawal
their lifetimes. Mild to moderate consumption (up to one drink/day for women and two drinks/day for men) has been shown to have beneficial cardiovascular effects, including a decreased risk of myocardial infarction and stroke, as well as overall decreased mortality (Box 154.1). Despite these possibly beneficial effects of alcohol, it has been found to be a top 10 cause of preventable deaths amo...
متن کاملOpioid withdrawal in the emergency setting
This topic review will discuss the clinical features and management of opioid withdrawal in the emergency setting. A summary table to facilitate emergent management is provided (table 1). Discussions of opioid withdrawal during detoxification treatment, opioid intoxication, opioid withdrawal in neonates, and general management of the poisoned patient are found elsewhere. (See "Medically supervi...
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ژورنال
عنوان ژورنال: Journal of Pain and Symptom Management
سال: 2007
ISSN: 0885-3924
DOI: 10.1016/j.jpainsymman.2006.09.010